Clinical data accumulated from over 20 years of controlled testing, including at least 21 double-blind
clinical trials, shows phosphatidylserine benefits practically all higher functions of the brain.(110, 211, 212)
Helps normalize brain biochemistry and physiology at every level.
Improves memory, learning and other cognitive functions in people
who are substantially impaired.
Improve depression and ease anxiety in people of all ages.
Help in coping with stress, both physical and emotional.
Potential to help children with attention and behavior
Improve activities of daily living and other quality of life for
people who suffer more severe memory loss.
As a dietary supplement, very well tolerated with virtually no
Because of stress, aging, modern eating habits and food-production methods.
Stress: Like burning a candle burning at both ends, stress increases the demand for
phosphatidylserine and depletes your phosphatidylserine levels at the same time. (128-133)
Aging: The elderly particularly benefit from taking phosphatidylserine. While aging
increases our brain’s need for phosphatidylserine it also creates digestive and metabolic inefficiency so
that it’s simply not possible to get enough phosphatidylserine in diet. Considerable research proves
that phosphatidylserine improves age-associated memory impairment and continued use prevents age-related
decay of brain functions. (126, 168)
Modern Diets: Modern low-fat and low-cholesterol diets lack up to 150 mg per day of
dietary phosphatidylserine. A vegetarian diet may undersupply as much as 200 to 250 mg per day. Other eating
styles also create a demand for more phosphatidylserine. For example, a diet deficient in omega-3 fatty
acids may reduce the amount of phosphatidylserine in the brain by 28% and thereby impair your brain’s
ability to form, store, process and remember. (135)
Modern Food Production: To make matters worse, modern industrial production of fats and
oils decreases all of the natural phospholipids—including phosphatidylserine. (135)
How Does PhosphatidylSerine Work?
Restores Neurotransmitters— Activity, Supply and Output
Phosphatidylserine enables your brain cells to metabolize glucose and to release and bind with
neurotransmitters, all of which is important to learning, memory and other cognitive functions. (127)
Phosphatidylserine increases communication between brain cells by increasing the number of membrane
receptor sites for receiving messages. Phosphatidylserine modulates the fluidity of cell membranes—essential
to your brain cells' ability to send and receive chemical communication. (14)
Restores Supply and Output of Acetylcholine
Studies demonstrate phosphatidylserine restores the brain’s supply and output of
acetylcholine, the neurotransmitter important to memory, and so may
turn back the clock in an aging brain. (126, 127, 168)
Phosphatidylserine restores acetylcholine release by maintaining an adequate acetylcholine supply. Phosphatidylserine can increase the availability of endogenous choline for de novo synthesis and release (128-131), while similar use of phosphatidylcholine (PC) had no effect. (132)
Stimulates Brain Dopamine
Phosphatidylserine restores dopamine release and benefits glutamatergic neurotransmission. Dopaminergic, glutamatergic and cholinergic neurotransmission play an important role in learning, memory and other cognitive functions. (133,299)
Persons diagnosed with clinical depression have shown marked improvement in their symptoms as a result of taking phosphatidylserine daily and this is likely connected to the finding that phosphatidylserine restores dopamine release. Reduced dopamine levels are also thought to contribute to attention deficit disorder and this natural substance has proven to be
an effective therapeutic agent for ADD and ADHD.(114, 128-133)
Normalizes Cortisol (Stress) and Speeds Recovery from Injury
Following intense weight-training, cortisol was significantly lower in subjects taking phosphatidylserine. (121,144,145)
A double-blind, placebo controlled study using 14 healthy and trained male athletes underwent cycling exercise prior to and following the supplementation period. Endurance was measured using a cycle ergometer at 85% VO2 max. After ten days, the group taking phosphatidylserine experienced about 30% more time before exhaustion, while the placebo group experienced no change. (258)
Important To Every Cell in Your Body
Phosphatidylserine is found in every cell in your body and the membrane proteins it activates are important in all your cells. Research shows phosphatidylserine is important to:
bone matrix formation,
beat coordination of the heart,
hormone secretion by the adrenal glands,
cell repair and removal by the immune system.(111,112)
Turn Back Brain-Aging with PhosphatidylSerine
Human clinical studies show phosphatidylserine may assist against the symptoms of dementia and
Age-Associated Memory Impairment (AAMI), also in reducing the risk of dementia and cognitive
A reversal of brain-aging of nearly 14 years was shown after 12 weeks of
supplementation with 300 mg per day of phosphatidylserine. Improvements were found in
learning and remembering written information, remembering names and recognizing people, and memory of
Children and young adults also get results in maintaining a sharp mind and controlling stress. Studies show
students experience improved learning abilities and performance. Placebo-controlled and double-blind trials
show that young university students experience significantly less stress from tests, stay
more clear-headed and composed, and keep a more stable mood when taking phosphatidylserine. (125)
What is PhosphatidylSerine?
Phosphatidylserine is a phospholipid (a fatty molecule) which contains both amino and fatty acids.
Phosphatidylserine is in every human cell and universally present in living things from the most simple
to the most complex. Phosphatidylserine has many known functions throughout all of our tissues and organs,
but is most important as a key building block for the billions of cells in your brain.
Phosphatidylserine is found mainly in the inner part of cell membranes where it acts as a signaling molecule and is involved in a number of enzymatic functions. While most tissues are no more than 3% phosphatidylserine, your brain and nerve cells are highly enriched with phosphatidlyserine, up to 18%. Nerve cells depend on phosphatidylserine for normal neuro-transmitter metabolism and nerve signal transmission. Maintaining brain levels of phosphatidylserine is associated to normal and efficient signal transduction processes, efficient glucose metabolism and healthy cognitive and mental functions.(291,336,337)
Phosphatidylserine is now available as a dietary supplement derived from soy lecithin. Decades of research
have established phosphatidylserine as the best single means for conserving memory and other
higher brain functions. Findings from controlled clinical trials show when intake of
phosphatidylserine is doubled, or better still quadrupled, as a dietary supplement, the majority of persons
derive measurable brain benefits. (211, 110)
Phosphorylated vs. Phosphatidyl
A phosphorylated serine is available as a dietary supplement but does not substitute for
phosphatidyl serine (PS), despite the claims of its
manufacturer. Though it resembles the head piece, phosphorylated serine is
different—it is not a phospholipid and does not work like PS does.
Consumers report phosphorylated serine can cause highly uncomfortable adverse reactions. Be
sure you get the real thing.
Phosphatidylserine in Flavay Plus® is extracted from soy which is confirmed non-GMO.
The phosphatidylserine in Flavay Plus® was the subject of many human clinical
trials regarding memory loss, mood, cognitive performance and learning ability.
The use of phosphatidylserine in Flavay Plus® is well validated through clinical
research and proven safe in standard toxicology tests.
The large number of human studies conducted on phosphatidylserine in Flavay Plus® produced a flawless safety record. First, it has proven compatible with a wide array of medications
including: antacids, anti-hypertensives, anti-inflammatories, anti-ulcer and mucolytic agents, diuretics,
anti-thrombotics, hypoglycemics, anti-arrhythmics, insulin, calcium channel blockers, calcitonin, chemotherapy
drugs and other prescription medications. Second, phosphatidylserine is well tolerated by elderly patients
with chronic diseases such as cerebrovascular, artery and vein disorders, heart diseases, high blood
pressure, diabetes, lung diseases, digestive system diseases and arthritis.
Interestingly, clinical researchers found phosphatidylserine lowered uric acid levels and liver SGPT in
their elderly patients—which can signify improved liver health. (106,110,114-117,119)
Authentic vs. “Borrowed” Science
Not all phosphatidylserine products are equal. The marketplace is full of inferior variations of
scientifically-proven products. Those who are looking for proven results—and not just claimed or implied results—want the authentic products proven in
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for my daughter's allergies. I want to tell you, the Flavay works like a charm for my daughter’s allergies. She is 6 years old, and when we ran out of capsules this week she told me, ‘You've got to get more Flavay!’”
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Validated by Patents and Clinical Trials Clinical Strength
14. Lombard, J. (board certified neurologist), et al. The brain wellness
plan - breakthrough medical, nutritional and immune-boosting therapies to
prevent and treat depression, alzheimer's disease, chronic fatigue syndrome,
attention deficit disorder, multiple sclerosis, parkinson's disease, lou
gehrig's disease. Kensington Pub. Corp. 1998.
106. Kidd, P.M. A review of nutrients and botanicals in the integrative management of cognitive dysfunction.
Altern Med Rev 1999 Jun;4(3):144-61.
109. Klinkhammer P., Szelies B., Heiss W.D. Effect of phosphatidylserine on cerebral glucose metabolism in
Alzheimer's disease. Dementia. 1990;1(4):197-201.
110. Kidd, P.M. Phosphatidylserine: the nutrient that accelerates all brain
functions and counters Alzheimer’s disease: Keats Pub. 1998.
111. Kidd, P.M. A review of nutrients and botanicals in the integrative management of cognitive dysfunction.
Altern Med Rev 1999 Jun;4(3):144-61.
112. Kidd, P.M. Phosphatidylserine (PS): A Remarkable Brain Cell Nutrient, Lucas Meyer, Inc. Third Edition April 1998.
114. Cenacchi T., et al. Cognitive decline in the elderly: A double-blind,
placebo-controlled multicenter study on efficacy of phosphatidylserine administration.
Aging, 5: 123–133, 1993.
115. Maggioni M., Picotti GB, Bondiolotti GP et al. Effects of phosphatidylserine
therapy in geriatric patients with depressive disorders. Acta Psychiatr
Scand. 81: 265–270, 1990.
116. Brambilla, F., Maggioni, M., Panerai, A.E., et al. Beta-endorphin concentration
in peripheral blood mononuclear cells of elderly depressed patients—effects
of phosphatidylserine therapy. Neuropsychobiology, 34: 18–21, 1996.
117. Monteleone P., Maj M., Beinat L., Natale M., Kemali, D. Blunting by
chronic phosphatidylserine administration of the stress-induced activation
of the hypothalamo-pituitary-adrenal axis in healthy men. Eur J Clin Pharm,
43: 385–388, 1992.
119. Funfgeld, E.W., Baggen, M., Nedwidek, P., Richstein, B., Mistlberger,
G. Double-blind study with phosphatidylserine (PS) in parkinsonian patients
with senile dementia of Alzheimer’s type (SDAT). Prog Clin Biol Res,
121. Fahey TD, Pearl MS: The Hormonal and Perceptive Effects of Phosphatidylserine Administration During Two Weeks of Weight Training-Induced Over-Training. Biol Sport 1998, 15(2):135-144.
124. Monteleone P., et al. Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans.
Neuroendocrinology 1990 Sep;52(3):243-8.
125. Benton D, et al. The influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor. Nutr Neurosci 2001;4(3):169-78.
126. Crook, T.H. Treatment of Age-Related Cognitive Decline: Effects of Phosphatidylserine in Anti-Aging 33
Medical Therapeutics,Vol II, edited by R.M. Klatz, Health Quest Publications, Chicago, 1998, 20-29.
127. Vannucchi, M.G., Pepeu, G. Effect of Phosphatidylserine on Acetylcholine Release and Content in
Cortical Slices From Aging Rats.Neurobiol Aging 1987, 8(5), 403-407.
128. Vannucchi, M.G., Casamenti, F., Pepeu, G. Decrease of acetylcholine release from cortical slices in
aged rats: investigations into its reversal by Phosphatidylserine. J. Neurochem 1990, 55, 819-25.
129. Pepeu, G., Giovanelli, L., Giovannini, M.G., Pedata, F. Effects of Phosphatidylserine on cortical
acetylcholine release and calcium uptake in adult and aging rats. In Phospholipid research and the
nervous system. Biochemical and molecular pharmacology. Horrocks, L.A., Freysz, L., Toffano, G. (Eds),
Liviana Press, Padova, 1986, 265-271.
130. Casamenti, F., Mantovani, P., Amaducci, L., Pepeu, G. Effect of phosphatidylserine on acetylcholine
output from the cerebral cortex of the rat. J. Neurochem 1979, 32, 529-533.
131. Casamenti, F., Scali, C., Pepeu, G. Phosphatidylserine reverses the age-dependent decrease in cortical
acetylcholine release: a microdialysis study, Eur. J. Pharmacol 1991, 194, 11-16.
132. Pedata, F., Giovannelli, L., Spignoli, G., Giovannini, M.G., Pepeu, G. Phosphatidylserine increases
acetylcholine release from cortical slices in aged rats. Neurobiol Aging 1985, 6, 337-339.
133. Mazzari, S., Battistella, A. Phosphatidylserine effects on dopamine release from striatum
synaptosomes. In: Multidisciplinary Approach to Brain Development. Benedetta, C., Balazs, R.,
Gombos, G., Porcellani, G. (Eds.). Elsevier/North Holland, Amsterdam, 1980, 569-570.
134. Monteleone, P., Beinat, L., Tanzillo, C., Maj, M., Kemali, D. Effects of Phosphatidylserine on the
Neuroendocrine Response to Physical Stress in Humans.Neuroendocrinology 1990, 52, 243-248.
135. Hamm, M. Ernährungswissenschaftliche Stellungnahme zur Veränderung der nutritiven Versorgung mit Phosphatidylserin (Nutritional-scientific statement
on the change of nutritive provision with phosphatidylserine), 2002.
136. Calderoni, G., Aporti, F., Bellini, F., Sonetti, A.C., Rubini, R., Telato, S., Xu, C., Canotti, A., Toffano, G.
Phospholipids as pharmacological tools in the aging brain. In: Horrocks, L.A., Kanfer, J.N.,
Porcellati, G. (Eds). Phospholipids in the nervous system,Vol II, Physiological roles. Raven Press,
New York, 1985, 11-19.
137. Kaibuchi, K., Takay, Y., Nishizuka, Y. Cooperative roles of various membrane phospholipids in the
activation of calcium-activated, phospholipid-dependent protein kinase. J. Biol. Chem. 1981, 256,
138. Raese, J., Patrick, R.L., Barchas, J.D. Phospholipid-induced activation of tyrosine hydroxylase from
rat brain striatal synaptosomes. Biochem Pharmacol 1976, 25, 2245-2250.
144. Burke, E.R., Fahey, T.D. Phosphatidylserine (PS): Promise for Athletic Performance.
Keats Pub. 1998,New Canaan, Connecticut, USA, ISBN: 0-87983-979-1.
145. Burke, E.R. PS: An Answer To Intense Training.Nutrition Science News 1998, 3, 252-253.
168. Schreiber S, Kampf-Sherf O, Gorfine M, Kelly D, Oppenheim Y, Lerer B. An open trial of plant-source derived phosphatidylserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci. 2000;37(4):302-7.
209. Crook, TH, et al. The Memory Cure: the safe, scientifically proven breakthrough that can slow, halt, or even reverse age-related memory loss, Simon & Schuster, NY 1998.
210. Talbott, S. The cortisol connection: why stress makes you fat and ruins your health, Hunter House Pub., CA 2002.
211. Kidd, PM. PS (PhosphatidylSerine): Nature's Brain Booster: a vital lipid nutrient for memory, mood and stress, Total Health Communications, 2005.
291. Pepeu G, et al. A review of phosphatidylserine pharmacological and clinical effects. Is phosphatidylserine a drug for the ageing brain? Pharmacol Res. 1996;33:73-80
299. Cohen, SA, et al. Age-related alterations of NMDA-receptor properties in the mouse forebrain: partial restoration by chronic phosphatidylserine treatment. Brain Research 1992, 584, 174-180.
330. Zeisel SH. Choline: an essential nutrient for humans. Nutrition. 2000 Jul-Aug;16(7-8):669-71.
331. Blum K, Chen AL, Braverman ER, et al. Attention-deficit-hyperactivity disorder and reward deficiency syndrome. Neuropsychiatr Dis Treat. 2008 Oct;4(5):893-918.
332. Kapur S, Mann JJ. Role of the dopaminergic system in depression. Biol Psychiatry. 1992 Jul 1;32(1):1-17.
336. Svennerholm L. Distribution and fatty acid composition of phosphoglycerides in normal human brain. J Lipid Res. 1968;9:570-579
337. Mozzi R, et al. Metabolism and functions of phosphatidylserine in mammalian brain. Neurochem Res. 2003;28:195-214
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